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Table 1 Revised Scoring System for the Diagnosis of Autoimmune Hepatitis6.

From: Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease

Parameter/Features Score
Gender  
- Female/Male +2/0
Degree of elevation above upper normal limit of ALP vs. aminotransferases  
- <1.5 +2
- 1.5 – 3.0 0
- >3.0 -2
Total serum globulins, γ-globulins, or IgG above normal  
- >2.0 +3
- 1.5 – 2.0 +2
- 1.0 – 1.5 +1
- <1.0 0
ANA, SMA or LKM-1 (titers by immunofluorescence on rodent tissues or HEp2-cells)  
- >1 : 80 +3
- 1 : 80 +2
- 1 : 40 +1
- <1 : 40 0
- AMA positive -4
Hepatitis viral markers (IgM anti-HAV, HBsAg, IgM anti-HBc, anti-HCV and HCV-RNA)  
- Positive/Negative -3/+3
Recent or current use of known or suspected hepatotoxic drugs  
- Yes/No -4/+1
Average alcohol intake  
- <25 g/day +2
- >60 g/day -2
Other autoimmune disease(s) in patient or first degree relatives  
- Yes/No +2/0
Optional additional parameters (should be allocated only if ANA, SMA or LKM-1 are negative)  
- HLA DR3, DR4, or other HLA with published association with AIH) +1
- Seropositivity for any of ANCA, anti-LC1, anti-SLA/LP, anti-ASGPR and anti-sulfatide +2
Liver histology  
- Interface hepatitis +3
- Predominant lymphoplasmacytic infiltrate +1
- Rosetting of liver cells +1
- None of the above -5
- Biliary changes -3
- Other changes -3
Response to therapy (as defined in Table 2)  
- Complete/Relapse +2/+3
  1. Definite AIH if greater than 15 before treatment or greater than 17 post-treatment; probable AIH if varies between 10–15 before treatment or 12–17 post-treatment. ALP: alkaline phospatase, IgM anti-HAV: hepatitis A virus IgM antibody, anti-HCV: hepatitis C virus antibody, HBsAg: surface antigen of hepatitis B virus, IgM anti-HBc: IgM antibody against the nuclear antigen of hepatitis B virus. Other abbreviations are the same as shown in the text.