Table 1 (Pro)insulin content of and release from pancreatic and hepatic tissue of transgenic and wild type NOD mice.
From: Insulin expressing hepatocytes not destroyed in transgenic NOD mice
PANCREAS | LIVER | |||
|---|---|---|---|---|
F2 progeny | (Pro)insulin content (ng/mg) | (Pro)insulin secretion (ng/mg tissue/ day) | (Pro)insulin content (ng/mg) | (Pro)insulin release in the presence of 100 nmol/l glucagon (ng/mg tissue/ day) |
Normoglycaemic transgenic (n = 5) | 6.3 ± 0.8 | 15.8 ± 1.6 | 0.5 ± 0.1 | 3.4 ± 1.0 |
Normoglycaemic wild type (n = 3) | 6.3 ± 1.0 | 15.2 ± 2.3 | ND | ND |
Diabetic transgenic (n = 5) | 0.5 ± 0.1 (n = 3; 2 ND) | ND (n = 3) | 0.6 ± 0.2 (n = 5) | 3.6 ± 0.3 (n = 3) |