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Table 1 (Pro)insulin content of and release from pancreatic and hepatic tissue of transgenic and wild type NOD mice.

From: Insulin expressing hepatocytes not destroyed in transgenic NOD mice

  PANCREAS LIVER
F2 progeny (Pro)insulin content (ng/mg) (Pro)insulin secretion (ng/mg tissue/ day) (Pro)insulin content (ng/mg) (Pro)insulin release in the presence of 100 nmol/l glucagon (ng/mg tissue/ day)
Normoglycaemic transgenic (n = 5) 6.3 ± 0.8 15.8 ± 1.6 0.5 ± 0.1 3.4 ± 1.0
Normoglycaemic wild type (n = 3) 6.3 ± 1.0 15.2 ± 2.3 ND ND
Diabetic transgenic (n = 5) 0.5 ± 0.1 (n = 3; 2 ND) ND (n = 3) 0.6 ± 0.2 (n = 5) 3.6 ± 0.3 (n = 3)
  1. ND – not detectable (<0.025 ng/mg tissue)
  2. Data expressed as X ± SD.