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Table 1 Statistical analysis for Therapeutic TNF-inhibitor gene therapy study:

From: Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis

 

Normal

ID

ID+AdTNFRI

CD4

0.34 ± 0.091

1.20 ± 0.45

0.80 ± 0.34

Anova p < 0.0001

   

   Normal

 

p < 0.0001

p = 0.008

   ID

  

p = 0.0003

CD8

0.49 ± 0.08

0.47 ± 0.14

1.63 ± 0.94

Anova p < 0.0001

   

   Normal

 

p = 1.00

p = 0.0002

   ID

  

p < 0.0001

RTLA

1.65 ± 0.84

13.2 ± 4.29

7.17 ± 2.81

Anova p < 0.0001

   

   Normal

 

p < 0.0001

p = 0.0001

   ID

  

p < 0.0001

CD18

0.17 ± 0.08

9.68 ± 2.55

5.53 ± 2.32

Anova p < 0.0001

   

   Normal

 

p < 0.0001

p < 0.0001

   ID

  

p < 0.0001

  1. 1 Mean ± SD
  2. 2 Pairwise comparison p-value with a Bonferroni correction.
  3. ID = induced dacryoadenitis; ANOVA = analysis of variance.
  4. Compared to ID group, AdTNFRI treated lacrimal glands have a significant decrease of CD4+ (p = 0.0003), RTLA+ (p < 0.0001) and CD18+ cells (p < 0.0001), and a significant increase of CD8+ cells in these treated glands (p < 0.0001).
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Journal of Autoimmune Diseases

ISSN: 1740-2557