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Table 1 Improvement of psoriasis cutaneous expression after therapyand MMPs or cytokine levels released in tissue culture supernantans

From: Decreased levels of metalloproteinase-9 and angiogenic factors in skin lesions of patients with psoriatic arthritis after therapy with anti-TNF-α

  Baseline values After 6 weeks Paired t P
PASI score 19.1 ± 7.8 7.4 ± 2.7 0.0002
TNF-α *(pg/ml) **0.12 294.7 ± 123.5 194.9 ± 67.8 0.02
MMP-9 *(ng/ml) **0.15 207.3 ± 240.6 43.3 ± 73.9 0.03
MMP-2 *(ng/ml) **0.16 1404.0 ± 1081.0 1205.0 ± 1142.0 0.048
VEGF *(pg/ml) **9.0 510.7 ± 376.6 240.6 ± 270.1 0.02
E-Selectin *(ng/ml) **0.1 18.9 ± 23.5 4.1 ± 3.3 0.05
  1. *Data are normalized per mg of tissue – **minimum detectable dose according to the manufacturer