Autoimmune hepatitis-specific antibodies against soluble liver antigen and liver cytosol type 1 in patients with chronic viral hepatitis

Table 1 Prevalence of non-organ specific autoantibodies detected by indirect immunofluorescence (IIFL) or enzyme linked immunosorbent assay (ELISA) in patients with chronic hepatitis C and B.

	Anti-LKM1 (IIFL)	Anti-LC1 (ELISA)	Anti-SLA (ELISA)	ANA (IIFL)	SMA (IIFL)
LKM1^pos/HCV^pos	18/18 (100%)*	6/18 (33%)	0/18 (0%)	5/18 (27.7%)**	6/18 (33%)***
LKM1^neg/HCV^pos	0/120 (0%)	1/120 (0.8%)	0/120 (0%)	45/120 (37.5%)**	61/120 (50.8%)***
LKM1^neg/HBV^pos	0/120 (0%)	0/120 (0%)	0/120 (0%)	23/120 (19.2%)**	15/120 (12.5%)***

LKM1, liver kidney microsomal type 1; LC1, liver cytosol type 1; SLA, soluble liver antigen; ANA, anti-nuclear antibody; SMA, smooth muscle antibody; pos, positive; neg, negative; *Confirmed by Western immunoblotting (see Methods section); **Low titers of ANA were detected in the three groups (mean titer: 1/168, 1/148 and 1/140, respectively); ***Low titers of SMA were detected in the three groups (mean titer: 1/134, 1/121 and 1/119, respectively).