The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders

Table 3 Comparisons of the parameters of the IAHG scoring system between patients with chronic liver diseases* achieving a probable (n = 8) and a negative AIH score (n = 415).

Characteristics	Negative score no. of patients (%)	Probable score no. of patients (%)	P-value
Gender
Female	225 (54.2)	6 (75)	NS
Male	190 (45.8)	2 (25)
ALP/ALT ratio
Positive: score +2	330 (79.5)	8(100)	NS
Negative: score 0, -2	85 (20.5)	0
Serum globulin or IgG above normal
Positive (score ≥ 1)	196 (47.2)	6 (75)	NS
Negative (score 0)	505 (57.9)	2 (25)
ANA, SMA or anti-LKM
Positive (titre ≥ 1:40)	327 (78.8)	8 (100)	NS
Negative	88 (21.2)	0
AMA
Positive (titre ≥ 1:40)	48 (11.6)	1 (12.5)	NS
Negative	367 (88.4)	7 (87.5)
Hepatitis viral markers
Yes	214 (51.6)	2 (25)	NS
No	201 (48.4)	6 (75)
History of illicit drug use
Yes	25 (6)	0	NS
No	390 (94)	8 (100)
Average alcohol intake
<25 g/day	318 (76.6)	7 (87.5)	NS
>60 g/day	97 (23.4)	1 (12.5)
Histological score
Positive (score > 0)	54 (13)	4 (50)	0.015**
Negative (score ≤ 0)	361 (87)	4 (50)
Aggregate histological score (mean ± SD)	-4.13 ± 3.3	0.88 ± 2.8	<0.001***
Other autoimmune disease
Yes	23 (5.5)	1 (12.5)	NS
No	392 (94.5)	7 (87.5)
Aggregate AIH score (mean ± SD)	2.29 ± 4.07	11.63 ± 1.19	<0.001***

Abbreviations are same as in text; NS: not statistically significant; SD: standard deviation; *Excluding AIH patients (n = 43) and patients with coincidence of AIH and any kind of liver disorder (n = 24); **Fisher's exact test; ***Mann-Whitney U test;