Table 4 Comparisons of the parameters of the IAHG scoring system between patients with chronic liver diseases* (n = 423) and patients with coincidence of AIH and any kind of liver disorder (n = 24).
Characteristics | Patients with liver diseases* no. of patients (%) | Patients with coincidence of AIH and any kind of liver disorder no. of patients (%) | P-value |
|---|---|---|---|
Gender | Â | Â | Â |
   Female | 231 (54.6) | 12 (50) | NS |
   Male | 192 (45.5) | 12 (50) |  |
ALP/ALT ratio | Â | Â | Â |
   Positive: score +2 | 338 (79.9) | 20 (83.3) | NS |
   Negative: score 0, -2 | 85 (20.1) | 4 (16.7) |  |
Serum globulin or IgG above normal | Â | Â | Â |
   Positive (score ≥ 1) | 202 (47.8) | 17 (70.8) | 0.035** |
   Negative (score 0) | 221 (52.2) | 7 (29.2) |  |
ANA, SMA or anti-LKM | Â | Â | Â |
   Positive (titre ≥ 1:40) | 335 (79.2) | 23 (95.8) | 0.06*** |
   Negative | 88 (20.8) | 1 (4.2) |  |
AMA | Â | Â | Â |
   Positive (titre ≥ 1:40) | 49 (11.6) | 4 (16.7) | NS |
   Negative | 374 (88.4) | 20 (83.3) |  |
Hepatitis viral markers | Â | Â | Â |
   Yes | 216 (51.1) | 8 (33.3) | NS |
   No | 207 (48.9) | 16 (66.7) |  |
History of illicit drug use | Â | Â | Â |
   Yes | 25 (5.9) | 0 | NS |
   No | 398 (94.1) | 24 (100) |  |
Average alcohol intake | Â | Â | Â |
   <25 g/day | 325 (76.8) | 21 (87.5) | NS |
   >60 g/day | 98 (23.2) | 3 (12.5) |  |
Histological score | Â | Â | Â |
   Positive (score > 0) | 58 (13.7) | 13 (54.2) | <0.001** |
   Negative (score ≤ 0) | 365 (86.3) | 11 (45.8) |  |
Aggregate histological score (mean ± SD) | -4 ± 3.3 | 0.38 ± 3.72 | <0.001**** |
Other autoimmune disease | Â | Â | Â |
   Yes | 24 (5.7) | 7 (29.2) | 0.001** |
   No | 399 (94.3) | 17 (70.8) |  |
Aggregate AIH score (mean ± SD) | 2.5 ± 4.2 | 10 ± 4.1 | <0.001**** |