The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders

Table 5 Comparisons of the parameters of the IAHG scoring system among patients with chronic liver diseases* (n = 423), AIH/overlap syndromes (n = 10) and patients with coincidence of AIH and other liver disease (n = 14).

Characteristics	Patients with liver diseases* no. of patients (%)	Patients with AIH/overlap syndromes no. of patients (%)	Patients with coincidence of AIH and other liver disease no. of patients (%)	P value
Gender
Female	231 (54.6)	5 (50)	7 (50)	NS
Male	192 (45.4)	5 (50)	7 (50)
ALP/ALT ratio
Positive: score +2	338 (79.9)	8 (80)	12 (85.7)	NS
Negative: score 0, -2	85 (20.1)	2 (20)	2 (14.3)
Serum globulin or IgG above normal
Positive (score ≥ 1)	202 (47.8)	7 (70)	10 (71.4)	NS
Negative (score 0)	221 (52.2)	3 (30)	4 (28.6)
ANA, SMA or anti-LKM
Positive (titre ≥ 1:40)	335 (79.2)	9 (90)	14(100)	NS
Negative	88 (20.2)	1 (10)	0
AMA
Positive (titre ≥ 1:40)	49 (11.6)	4 (40)	0	0.009**
Negative	374 (88.4)	6 (60)	14(100)
Hepatitis viral markers
Yes	216 (51.1)	0	8 (57.1)	0.005**
No	207 (48.9)	10 (100)	6 (42.9)
History of illicit drug use
Yes	25 (5.9)	0	0	NS
No	398 (94.1)	10 (100)	14 (100)
Average alcohol intake
<25 g/day	325 (76.8)	10 (100)	11 (78.6)	0.013**
>60 g/day	98 (23.2)	0	3 (21.4)
Histological score
Positive (score > 0)	58 (13.7)	3 (30)	10 (71.4)	<0.001**
Negative (score ≤ 0)	365 (86.3)	7 (70)	4 (28.6)
Aggregate histological score (mean ± SD)	-4± 3.3	-2.1± 4.4	2.14± 1.7	<0.001***
Other autoimmune disease
Yes	24 (5.7)	5 (50)	2 (14.3)	<0.001**
No	399 (94.3)	5 (50)	12 (85.7)
Aggregate AIH score (mean ± SD)	2.5 ± 4.23	9.3 ± 4.8	10.5 ± 3.7	<0.001***

Abbreviations are same as in text; NS: not statistically significant; SD: standard deviation; *Excluding AIH patients (n = 43) and patients with coincidence of AIH and any kind of liver disorder (n = 24); **Total x square (comparison amongst the three groups of patients; for statistical significance between groups see text of results; subheading Comparison between groups, second paragraph); ***Kruskal-Wallis test (comparison amongst the three groups of patients; for statistical significance between groups see text of results, subheading Comparison between groups, second paragraph).