Table 6 Comparisons of the parameters of the IAHG scoring system among patients with AIH/overlap syndromes (n = 10), coincidence of AIH and other liver disease (n = 14) and AIH patients (n = 43).
Characteristics | Patients with AIH/overlap syndromes no. of patients (%) | Patients with coincidence of AIH and other liver disease no. of patients (%) | Patients with AIH no. of patients (%) | P value |
|---|---|---|---|---|
Gender | Â | Â | Â | Â |
   Female | 5 (50) | 7 (50) | 33 (76.7) | NS |
   Male | 5 (50) | 7 (50) | 10 (23.3) |  |
ALP/ALT ratio | Â | Â | Â | Â |
   Positive: score +2 | 8 (80) | 12 (85.7) | 41 (95.3) | NS |
   Negative: score 0, -2 | 2 (20) | 2 (14.3) | 2 (4.7) |  |
Serum globulin or IgG above normal | Â | Â | Â | Â |
   Positive (score ≥ 1) | 7 (70) | 10 (71.4) | 34 (79.1) | NS |
   Negative (score 0) | 3 (30) | 4 (28.6) | 9 (20.9) |  |
ANA, SMA or anti-LKM | Â | Â | Â | Â |
   Positive (titre ≥ 1:40) | 9 (90) | 14 (100) | 43(100) | 0.055* |
   Negative | 1 (10) | 0 | 0 |  |
AMA | Â | Â | Â | Â |
   Positive (titre ≥ 1:40) | 4 (40) | 0 | 0 | <0.001* |
   Negative | 6 (60) | 14(100) | 43 (100) |  |
Hepatitis viral markers | Â | Â | Â | Â |
   Yes | 0 | 8 (57.1) | 0 | <0.001* |
   No | 10 (100) | 6 (42.9) | 43 (100) |  |
History of illicit drug use | Â | Â | Â | Â |
   Yes | 0 | 0 | 1 (2.3) | NS |
   No | 10 (100) | 14 (100) | 42 (97.7) |  |
Average alcohol intake | Â | Â | Â | Â |
   <25 g/day | 10 (100) | 11 (78.6) | 42 (97.7) | 0.022* |
   >60 g/day | 0 | 3 (21.4) | 1 (2.3) |  |
Histological score | Â | Â | Â | Â |
   Positive (score > 0) | 3 (30) | 10 (71.4) | 35 (81.4) | 0.005* |
   Negative (score ≤ 0) | 7 (70) | 4 (28.6) | 8 (18.6) |  |
Aggregate histological score (mean ± SD) | -2.1 ± 4.4 | 2.14 ± 1.7 | 2.73 ± 1.98 | 0.001** |
Other autoimmune disease | Â | Â | Â | Â |
   Yes | 5 (50) | 2 (14.3) | 25 (58.1) | NS |
   No | 5 (50) | 12 (85.7) | 18 (41.9) |  |
Aggregate AIH score (mean ± SD) | 9.3 ± 4.8 | 10.5 ± 3.7 | 17 ± 3.05 | <0.001** |