Skip to main content

Table 6 Comparisons of the parameters of the IAHG scoring system among patients with AIH/overlap syndromes (n = 10), coincidence of AIH and other liver disease (n = 14) and AIH patients (n = 43).

From: The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders

Characteristics Patients with AIH/overlap syndromes no. of patients (%) Patients with coincidence of AIH and other liver disease no. of patients (%) Patients with AIH no. of patients (%) P value
Gender     
   Female 5 (50) 7 (50) 33 (76.7) NS
   Male 5 (50) 7 (50) 10 (23.3)  
ALP/ALT ratio     
   Positive: score +2 8 (80) 12 (85.7) 41 (95.3) NS
   Negative: score 0, -2 2 (20) 2 (14.3) 2 (4.7)  
Serum globulin or IgG above normal     
   Positive (score ≥ 1) 7 (70) 10 (71.4) 34 (79.1) NS
   Negative (score 0) 3 (30) 4 (28.6) 9 (20.9)  
ANA, SMA or anti-LKM     
   Positive (titre ≥ 1:40) 9 (90) 14 (100) 43(100) 0.055*
   Negative 1 (10) 0 0  
AMA     
   Positive (titre ≥ 1:40) 4 (40) 0 0 <0.001*
   Negative 6 (60) 14(100) 43 (100)  
Hepatitis viral markers     
   Yes 0 8 (57.1) 0 <0.001*
   No 10 (100) 6 (42.9) 43 (100)  
History of illicit drug use     
   Yes 0 0 1 (2.3) NS
   No 10 (100) 14 (100) 42 (97.7)  
Average alcohol intake     
   <25 g/day 10 (100) 11 (78.6) 42 (97.7) 0.022*
   >60 g/day 0 3 (21.4) 1 (2.3)  
Histological score     
   Positive (score > 0) 3 (30) 10 (71.4) 35 (81.4) 0.005*
   Negative (score ≤ 0) 7 (70) 4 (28.6) 8 (18.6)  
Aggregate histological score (mean ± SD) -2.1 ± 4.4 2.14 ± 1.7 2.73 ± 1.98 0.001**
Other autoimmune disease     
   Yes 5 (50) 2 (14.3) 25 (58.1) NS
   No 5 (50) 12 (85.7) 18 (41.9)  
Aggregate AIH score (mean ± SD) 9.3 ± 4.8 10.5 ± 3.7 17 ± 3.05 <0.001**
  1. Abbreviations are same as in text; NS: not statistically significant; SD: standard deviation; * Total x square (comparison amongst the three groups of patients; for statistical significance between groups see text of results, subheading Comparison between groups, third paragraph); **Kruskal-Wallis test (comparison amongst the three groups of patients; for statistical significance between groups see text of results, subheading Comparison between groups, third paragraph).